Characterization of Mammary Plaques in DDD Mice Congenic forMtv-2Gene, DDD/1-Mtv-2/Mtv-2

BALB/Mtv-null mice responding to strong mouse mammary tumor virus superantigens restrict mammary tumorigenesis.

The absence of endogenous mouse mammary tumor viruses (MMTVs) in the congenic mouse strain, BALB/Mtv-null, restricts the early steps of exogenous C3H MMTV infection, preventing the superantigen (Sag) response and mammary tumorigenesis. Here we demonstrate that BALB/Mtv-null mice also resist tumor induction by FM MMTV, which encodes a stronger Sag compared to C3H MMTV. In contrast to infections ...

Immunology of the mouse mammary tumor virus (MTV) : identification in vitro of mouse antibodies against MTV.

Immunology of the mouse mammary tumor virus (MTV): neutralization of MTV by mouse antiserum.

years; antisera from rabbits, rats, and guinea pigs immunized with MTV-containing tissue extracts are capable of neutralizing the biologic activity of the virus (1, 2, 3, 6, 9). More recently, it has been demonstrated that MTV is also immunogenic in the mouse; antisera from immunized mice react with MTV antigen in immunodiffusion to produce a precipitate line specific for MTV (5, 11). The prese...

The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire

Most laboratory strains of mice have between two and eight endogenous superantigens. These viral superantigens (vSAGs) are coded by genes in the 3' long terminal repeats of endogenous mammary tumor viruses (Mtv's). A line of Mtv-negative mice and several lines of mice containing single Mtv's were created by inbreeding the F2 progeny of CBA/CaJ and C58/J mice, which have no Mtv integrants in com...

Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain

The GR/Mtv-2- mouse strain is congenic to the GR strain but lacks the Mtv-2 gene for high amounts of mouse mammary tumor virus (MMTV) virion particles in the milk and early mammary tumors. With a sensitive competition radioimmunoassay for individual viral proteins of MMTV, substantial amounts of the gag proteins p27 and p10 could still be detected in extracts of the mammary glands of GR/Mtv-2- ...